Endocannabinoids: New Physiological (Co-)Agonists of Human Platelets

• References

• 1 Fox JE. Cytoskeletal proteins and platelet signaling. Thromb Haemost 2001; 86: 198-213.
• 2 Furie B, Furie BC, Flaumenhaft R. A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion. Thromb Haemost 2001; 86: 214-21.
• 3 Phillips DR, Nannizzi-Alaimo L, Prasad KS. Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb Haemost 2001; 86: 246-58.
• 4 Howlett AC, Mukhopadhyay S. Cellular signal transduction by anandamide and 2-arachidonoylglycerol. Chem Phys Lipids 2000; 108: 53-70.
• 5 Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE. et al. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci USA 2001; 98: 3662-5.
• 6 Kunos G, Jarai Z, Batkai S, Goparaju SK, Ishac EJ, Liu J. et al. Endocan nabinoids as cardiovascular modulators. Chem Phys Lipids 2000; 108: 159-68.
• 7 Maccarrone M, Bari M, Battista N, Finazzi-Agrò A. Endocannabinoid degradation, endotoxic shock and inflammation. Current Drug Targets -Inflammation & Allergy 2002; 02: 53-63.
• 8 Batkai S, Jarai Z, Wagner JA, Goparaju SK, Varga K, Liu J. et al. Endo cannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nature Med 2001; 07: 827-32.
• 9 Maccarrone M, Bari M, Menichelli A, Giuliani E, Del Principe D, Finazzi-Agrò A. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. Eur J Biochem 2001; 268: 819-25.
• 10 Daniel JL, Dangelmaier C, Jin J, Ashby B, Smith JB, Kunapuli SP. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 1998; 273: 2024-9.
• 11 Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S. et al. A dual thrombin receptor system for platelet activation. Nature 1998; 394: 690-4.
• 12 Braud S, Bon C, Touqui L, Mounier C. Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid. FEBS Lett 2000; 471: 12-6.
• 13 Maccarrone M, Finazzi-Agro A. Platelet activation: a new vascular activity of anandamide. FEBS Lett 2000; 483: 84-5.
• 14 Maccarrone M, De Petrocellis L, Bari M, Fezza F, Salvati S, Di Marzo V. et al. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Arch Biochem Biophys 2001; 393: 321-28.
• 15 Berdyshev EV, Schmid PC, Krebsbach RJ, Schmid HH. Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. FASEB J 2001; 15: 2171-8.